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|
Genes Ids
|
Uniprot Id
|
Gene name
|
Gene expression (Log2 fold change vs non-COPD)
|
Ref
|
HPAa
|
SCb
|
|---|
|
Whole lung
| |
GSE47460
|
GSE57148
|
GSE76925
|
GSE103174
| | |
%
|
P
|
|---|
|
BBS7
|
Q8IWZ6
|
Bardet-Biedl syndrome 7 protein
| |
0.21
|
− 0.29
|
− 0.06
| |
MCC
|
+
|
All
|
|
BBS9
|
Q3SYG4
|
Bardet-Biedl syndrome 9 protein
|
− 0.01
|
0.13
|
0.04
| |
[6]
|
MCC
|
+ +
|
MCC
|
|
CALM3
|
P0DP25
|
Calmodulin-3
|
0.02
|
0.11
|
0.03
| | |
MCC
|
+ + +
|
All
|
|
CEP78
|
Q5JTW2
|
Centrosomal protein of 78 kDa
| |
0.10
|
0.10
|
− 0.05
| |
NDC
|
+ +
|
MCC
|
|
DZIP1
|
Q86YF9
|
DAZ-interacting protein ½
|
0.02
|
0.22
|
0.11
| | |
MCC
|
+ +
|
MCC
|
|
GLI2
|
P10070
|
GLI family zinc finger protein 2
|
0.04
|
0.20
|
0.20
| |
[17, 18]
|
All
|
+
|
All
|
|
NEK6
|
Q9HC98
|
Never in mitosis A-related kinase 6
|
0.05
|
0.40
|
0.09
|
0.08
|
[19]
|
EC
|
+
|
All
|
|
NUBP2
|
Q9Y5Y2
|
Nucleotide-binding protein 2
|
− 0.01
|
− 0.56
|
0.09
| | |
All
|
+ +
|
All
|
|
PDE6D
|
O43924
|
Retinal rod rhodopsin-sensitive cGMP 3′,5′-cyclic phosphodiesterase subunit delta
|
0.01
|
− 0.17
|
0.03
| | |
All
|
+
|
All
|
|
PRPF4
|
O43172
|
U4/U6 small nuclear ribonucleoprotein Prp4
| |
0.15
|
0.03
|
0.04
| |
All
|
+
|
All
|
|
PRPF8
|
Q6P2Q9
|
Pre-mRNA-processing-splicing factor 8
|
− 0.01
|
0.34
|
0.02
| | |
All
|
+ +
|
All
|
|
PTPDC1
|
A2A3K4
|
Protein tyrosine phosphatase domain-containing protein 1
|
− 0.02
|
0.12
|
0.04
| | |
NDC
|
+
|
All
|
|
TMEM138
|
Q9NPI0
|
Transmembrane protein 138
|
0.02
|
− 0.18
|
0.06
| | |
MCC
|
+ +
|
MCC
|
|
WDPCP
|
095876
|
WD repeat-containing and planar cell polarity effector protein fritz homolog
|
− 0.02
|
0.21
| |
− 0.09
|
[20]
|
EC
|
+ +
|
MCC
|
|
Genes Ids
|
Uniprot Id
|
Gene name
|
Gene expression (Log2 fold change vs non-COPD)
|
Ref
|
HPAa
|
SCb
|
|---|
|
Small airway epithelial cells (SAEC)
| |
GSE11784
|
GSE37147
|
GSE56341
| | | |
%
|
P
|
|---|
|
ADAM15
|
Q13444
|
Disintegrin and metalloproteinase domain-containing protein 15
| |
0.04
|
0.07
| |
[21, 24]
|
MCC
|
+
|
All
|
|
ADCY6
|
O43306
|
Adenylate cyclase type 6
| |
0.02
|
0.02
| | |
MCC
|
+
|
EC
|
|
ANKMY2
|
Q8IV38
|
Ankyrin repeat and MYND domain-containing protein 2
|
0.35
|
− 0.01
| | | |
ND
|
+
|
All
|
|
ARMC4
|
Q5T2S8
|
Armadillo repeat-containing protein 4
| |
− 0.02
|
− 0.02
| | |
MCC
|
+ + +
|
MCC
|
|
BBS4
|
Q96RK4
|
Bardet-Biedl syndrome 4 protein
| |
− 0.03
|
− 0.03
| | |
EC
|
+ +
|
MCC
|
|
DCDC2
|
Q9UHG0
|
Doublecortin domain-containing protein 2
| |
− 0.03
|
− 0.05
| |
[22, 23]
|
All
|
+ +
|
MCC
|
|
EFCAB2
|
Q5VUJ9
|
Dynein regulatory complex protein 8
| |
− 0.03
|
− 0.05
| | |
MCC
|
+ + +
|
MCC
|
|
PROM2
|
Q8N271
|
Prominin-2
|
0.55
|
0.04
|
0.06
| | |
EC
|
+ +
|
EC
|
|
TTC23
|
Q5W5X9
|
Tetratricopeptide repeat protein 23
| |
− 0.02
|
− 0.04
| | |
All
|
+
|
All
|
|
WDR34
|
Q96EX3
|
Cytoplasmic dynein 2 intermediate chain 2
|
0.40
|
0.01
| | |
[6]
|
EC
|
+ + +
|
MCC
|
- aHPA, Human Protein Atlas protein localization (cell population)
- bSC, Single cell transcriptomic signature: % (percentage of cell expressing the transcript of interest; + , low (< 25%); + + , intermediate (25–50%); + + + , high (> 50%)) and P (principal cell population expressing the transcript of interest); MCC multiciliated cells, NDC non-differentiated cells, EC epithelial cells, All, epithelial and non-epithelial cells; ND not detected
