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Table 4 Longitudinal association between decreased telomere length and lung function and clinical variables during 10 year-follow-up

From: Telomere length dynamics over 10-years and related outcomes in patients with COPD

  Total patients (n = 134) Deaths during follow-up (n = 43) Alive patients (n = 91)
  β p-value β p-value β p-value
FEV1 (L) 0.13 0.022 0.17 0.112 0.11 0.104
FEV1 (% pred) 0.56 0.784 2.91 0.501 0.59 0.798
FEV1/FVC (% pred) 0.445 0.0008 0.579 0.024 0.377 0.015
PaO2 0.771 < 0.0001 1.398 0.0003 0.443 0.053
IC/TLC (%) 0.006 < 0.0001 0.006 0.021 0.006 0.0009
KCO 0.877 0.042 1.325 0.092 0.817 0.106
6MWD (mts) 4.655 0.004 10.53 0.007 1.769 0.299
BODE index − 0.081 0.009 − 0.219 0.002 − 0.013 0.689
  1. Linear regression of mixed models. β, coefficient
  2. FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, % pred per cent predicted, PaO2 partial oxygen tension, KCO transfer factor coefficient of the lung for carbon monoxide, which is DLCO, IC/TLC inspiratory capacity to total lung capacity ratio, 6MWD 6 min walking distance test. p-values < 0.05 are shown in italics
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Respiratory Research

ISSN: 1465-993X

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