Telomere length dynamics over 10-years and related outcomes in patients with COPD

Respiratory Research

Table 3 Characterization of patients with COPD (N = 42) at baseline and at 10 years of follow-up

Variable	Baseline	10 year-follow-up	p-value
T/S ratio^a	0.62 ± 0.22	0.45 ± 0.14	< 0.0001
TL (bp)^a	7583 ± 2328	5755 ± 1455	< 0.0001
BMI^a	27 ± 6	27 ± 6	0.981
Active smoking (%)	52	40	< 0.0001
FEV₁ (L)^a	1.61 ± 0.61	1.36 ± 0.57	< 0.0001
FEV₁ (% pred)^a	61 ± 19	56 ± 18	0.014
FVC (% pred)^a	90 ± 23	86 ± 24	0.043
FEV₁/FVC (% pred)^a	54 ± 10	51 ± 10	0.022
PaO₂^a	73 ± 10	68 ± 10	< 0.0001
K_CO^a	90 ± 28	76 ± 24	0.006
IC/TLC (%)^a	36 ± 8	31 ± 9	0.001
6MWD (mts)^a	520 ± 84	448 ± 125	< 0.0001
mMRC dysnea^b	1 (0–1)	1 (0–2)	0.209
BODE index^b	1 (0–2)	1 (0–3)	0.003
Charlson index^b	0 (0–1)	1 (0–1)	< 0.0001

Paired sample t test was used
T/S ratio relative telomere length, TL telomere length in base pairs, BMI body mass index, FEV₁ forced expiratory volume in 1 s, FVC forced vital capacity, % pred per cent predicted, PaO₂ partial oxygen tension, K_CO transfer factor coefficient of the lung for carbon monoxide, which is DL_CO, IC/TLC inspiratory capacity to total lung capacity ratio, SMWD 6 min walking distance test. p-values < 0.05 are shown in italics
^aData are presented as mean ± SD
^bData are presented as median (25th–75th pc)

ISSN: 1465-993X