Telomere length dynamics over 10-years and related outcomes in patients with COPD

Respiratory Research

Table 2 Baseline characterization of COPD patients who achieved 10 years of follow-up and those who died

Variable	Total patients included (n = 134)	Alive after 10 year-follow-up (n = 42)^‡	Died during 10 year-follow-up (n = 43)^‡	p-value^‡
Age	64 9	61 ± 8	69 ± 9	0.001
BMI^a	27 ± 5	27 ± 6	28 ± 5	0.781
Smoking habit (pack-year)^a,c	65 ± 26	61 ± 22	70 ± 31	0.139
Active smoking (%)	43	52	33	0.069
FEV₁ (L)^a	1.52 ± 0.62	1.61 ± 0.61	1.34 ± 0.56	0.038
FEV₁ (% pred)^a	58 ± 21	61 ± 19	51 ± 21	0.027
FVC (% pred)^a	89 ± 24	90 ± 23	81 ± 25	0.070
FEV₁/FVC (% pred)^a	51 ± 11	54 ± 10	49 ± 11	0.024
PaO₂^a	72 ± 11	73 ± 10	68 ± 10	0.015
K_CO^a	80 ± 26	90 ± 28	74 ± 23	0.009
IC/TLC (%)^a	34 ± 8	35 ± 8	33 ± 8	0.143
6MWD (mts)^a	495 ± 90	522 ± 83	474 ± 75	0.008
mMRC dysnea^b	1 (0–2)	1 (0–1)	1 (0–2)	0.703
BODE index^b	1 (0–3)	1 (0–2)	1 (0–3)	0.179
Charlson index^b	0 (0–1)	0 (0–1)	1 (0–1)	0.740

Paired sample t test was used
BMI body mass index, FEV₁ forced expiratory volume in 1 s, FVC forced vital capacity, % pred per cent predicted, PaO₂ partial oxygen tension, K_CO transfer factor coefficient of the lung for carbon monoxide, which is DL_CO, IC/TLC inspiratory capacity to total lung capacity ratio, SMWD 6 min walking distance test
^‡p-value between compared groups
^aData are presented as mean ± SD
^bData are presented as median (25th–75th pc)
^cNumber of packs of cigarettes smoked per day × number of years smoking

ISSN: 1465-993X